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EXOAI TM

exoai

Exosomal lipid formulation (PC, PE, cholesterol ...)

Biocompatibility Safety Requires appropriate composition

Active Pharmaceutical lngredients (API : miRNAs, siRNAs ...)

Gene therapy Regenerative medicine Requires disovery of potential APIs

Exosomal protein (Transpanin, CD9, CD73 ...)

Tropism Long circulation time High-efficiency, Low-cost protein production
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100nm

Workflow of the EXOAI TM

workflow

Parameter Selection

Select therapeutic cargo for nanoparticle encapsulation
Disease Option
API Option
Cargo Option

Selected Parameters

Disease : Cell Type : Cargo :
All cargo molecules validated for nanoparticle delivery Laboratory of Biochip Technology, Yonsei University © 2024

Critical Material Attributes (CMAs)

  • DC-CHOL 20% - 50%
  • CHOL 0% - 30%
  • SM 5% - 25%
  • PC 10% - 25%
  • PS 5% - 20%
  • PE 5% - 20%
Total: 100.0%

Critical Quality Attributes (CQAs)

  • Particle Size 140.2 nm
  • Zeta Potential -14.8 mV
  • PDI 0.221
  • Encapsulation Efficiency 93.0%

Critical Process Parameters (CPPs)

  • Temperature 24.0°C
  • Flow Rate 2.58 mL/min
  • Flow rate ratio 1:3

Exosome Image

exosome